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Golimumab, which is available in Australia under the brand name Simponi for people with diseases such as rheumatoid arthritis, ulcerative colitis, psoriatic arthritis and ankylosing spondylitis, is an anti-tumor-necrosis-factor (TNF) therapy, which is generally administered subcutaneously, once per month, via a pre-filled syringe or through the SmartJect autoinjector. 

Golimumab has now shown that it can also preserve beta-cell function in children and young adults with newly diagnosed Type 1 diabetes.  

In a stage 2 study by a University at Buffalo, it was also demonstrated that golimumab reduced the amount of injected insulin required by children and young adults with newly diagnosed Type 1 diabetes by preserving their endogenous insulin production. Patients treated with golimumab had a higher C-peptide level at week 52 compared to placebo. 

The findings were presented at the annual meeting of the American Diabetes Association 

Reference: https://medicalxpress.com/news/2020-06-golimumab-beta-cell-function-children-young.html#:~:text=In%20research%20led%20by%20a,from%20a%20Phase%202%20study